Do Polynucleotides Work?

Polynucleotides are often called the building blocks of DNA. When injected into the dermal layers, they switch on the skin's own repair signals. The molecules support tissue repair, boost collagen and elastin, and improve hydration from the inside.

Here is what happens step by step:

• The polynucleotide solution is gently injected into the targeted area using a fine needle or cannula.
• The skin recognises the molecules and starts a natural healing response.
• Fibroblast cells get stimulated, producing fresh collagen and elastin.
• The skin retains more moisture due to higher hyaluronic acid synthesis.
• Over weeks, texture, tone, firmness and brightness gradually improve.

Yes, polynucleotides are one of the most popular treatments for tired, dark under-eye areas. They reduce pigmentation, plump thin crepey skin and improve overall brightness.

Studies show that polynucleotide treatment can improve under-eye brightness by over 32 per cent in as little as 4 weeks, while increasing skin elasticity by an average of 22 per cent. That is a meaningful difference for an area that often refuses to respond to creams and serums.

However, there is one honest point worth noting:

• Polynucleotides do not fill deep tear troughs the way hyaluronic acid filler does.
• They rejuvenate the skin and subtly soften the look of hollows by plumping the surrounding tissue.
• For very deep volume loss, a tear trough filler may be the better structural option.

Many people benefit most from a careful assessment first because pigmentation, thin skin, shadowing, or volume loss can cause dark circles, and the right treatment depends on the cause.

Yes, polynucleotides genuinely help with acne scarring, especially when combined with the right supporting treatment. The molecules trigger tissue repair, boost collagen production, and improve overall skin texture, helping soften the appearance of pitted and uneven scars.

The best results usually come from a combined approach:

• Subcision, which physically releases the tethered scar tissue beneath the skin.
• Polynucleotide injections help the released tissue heal smoothly with new collagen.

This pairing is far more effective than either treatment alone. If you are wondering how to treat acne scarring properly, a layered approach is almost always the best route.

Polynucleotide therapy is not limited to the under-eye area. Doctors can use it on multiple areas where the skin needs better quality, firmness, or texture. Common treatment areas include:

Because the product is water-like and works on a cellular level, it sits comfortably in delicate areas where thicker fillers are not suitable. Learn more about our polynucleotide treatment in Sheffield.

The benefits go beyond looking refreshed. Polynucleotides actively support long-term skin health. Key benefits include:

• Boosts collagen production to strengthen skin structure and reduce wrinkles.
• Aids tissue repair to enhance skin health.
• Helps reduce under-eye dark circles by decreasing pigmentation.
• Promotes cell turnover for an overall brighter complexion.
• Acts as an antioxidant defence system to combat free radicals.
• Minimal downtime, so most people return to normal life quickly.
• Long-lasting results with simple maintenance every 9 to 12 months.

This combination is what makes polynucleotides feel different from traditional aesthetic injectables. It is rejuvenation rather than just correction.

Both are skin boosters, but they work differently:

Polynucleotides can be used around the eyes and on the forehead, whilst Profhilo cannot. Doctors can use both treatments on the cheeks, neck, décolletage, and stomach. Both treatments also require an initial course followed by maintenance sessions. The right choice depends on what your skin actually needs, so a proper consultation helps doctors make the best decision instead of relying on guesswork.

It depends entirely on what you want to treat.

• If your concern is only deep hollows, with no puffiness, then tear trough filler is usually the better option because it physically replaces lost volume.
• If your concerns are fine lines, crepey skin, dark circles, puffiness, or eye bags, then polynucleotides are the safer, more natural choice.

Tear trough filler can sometimes make the under-eye look puffier because hyaluronic acid attracts water and can shift over time. Polynucleotides do not fill the area or migrate, so the result tends to look more natural and avoid the ‘done’ look.

The recovery process depends on the method chosen:

Mild redness, light bruising or tenderness can occur, but these are short-lived. Most people return to their normal daily lives very quickly, which is why this treatment fits well into busy routines.

Polynucleotides have an excellent safety profile. Because they are derived from purified salmon DNA fragments and work with the body's own repair systems, the risk of allergic reaction or rejection is very low.

A proper medical consultation is the only reliable way to confirm whether this treatment is right for your skin.

Results typically last 9 to 12 months, depending on factors such as:

• Individual metabolism and skin type
• Lifestyle, diet and hydration
• Sun exposure and skincare routine
• Maintenance sessions

A single maintenance treatment every 9 to 12 months is generally enough to keep the skin looking refreshed and supported.

Do polynucleotides have any effect? Yes, they provide reliable, scientifically backed results for dark circles, fine lines, crepe skin, acne scars, and general skin conditions, without surgery or downtime. Doctors should explain one simple fact upfront: polynucleotides rejuvenate the skin but do not add volume, so deep hollows require a different solution.

The advantage of this procedure is that it works through skin regeneration. It respects the skin's natural function, improves skin condition over time, and produces natural results when applied correctly. The key components in this case are proper diagnosis and an individualised treatment protocol.

If you would like a clear, doctor-led plan for your skin concerns, the medical team at The Skin Firm offers expert polynucleotide treatment in Sheffield tailored to your unique needs.